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Chronic pancreatitis (CP) has been considered an intractable inflammatory disease that is progressive and irreversible after definite structural changes appear in the pancreas. The Japanese diagnostic criteria for CP were revised ...
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Chronic pancreatitis (CP) has been considered an intractable inflammatory disease that is progressive and irreversible after definite structural changes appear in the pancreas. The Japanese diagnostic criteria for CP were revised in 2009. One of the reasons for this revision was to define a diagnostic criterion for the early phase of CP (early CP) to improve a patient's clinical outcome, because the disease progression might be reversed in this phase by a therapeutic intervention. However, the clinical features and outcome of early CP remain largely unknown, and the diagnostic reliability of early CP needs to be verified. Here, we show two patients who met the diagnostic criteria of early CP and then progressed to the advanced, late phase of CP (definite CP). A 64-year-old man with recurrent acute pancreatitis was diagnosed as early CP and later progressed to definite CP with multiple pancreatic calcifications at the age of 69. The etiology of CP in this patient was thought to be idiopathic. The other patient was a 57-year-old man with alcohol abuse (ethanol consumption > 120 g/day). He was diagnosed as early CP and then rapidly progressed to definite CP without any acute attack. He could not remain abstinent after the diagnosis of early CP. In the present report, we retrospectively demonstrated distinct clinical features of the two patients, both of whom were diagnosed as early CP first and then progressed to definite CP. Thus, our findings support the disease concept of early CP and also suggest the validity of the revised Japanese criteria for the diagnosis of early CP.
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Objective To investigate the demographic features, etiology and clinical characteristics of chronic pancreatitis (CP). Methods We retrospectively analyzed the records of 346 CP cases hospitalized in Peking Union Medical College Ho...
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Objective To investigate the demographic features, etiology and clinical characteristics of chronic pancreatitis (CP). Methods We retrospectively analyzed the records of 346 CP cases hospitalized in Peking Union Medical College Hospital during the period of January 1983 to December 2008, summarizing the demographic features, clinical manifestations, causes of disease, and complications of these patients. Results The 346 CP cases included 267 males and 79 females (M/F ratio=3.38:1). The mean age of onset was (44.34±15.88) years. Most of the patients were Han Chinese (94.80%, 328/346), and a large proportion were cadres (32.08%, 111/346). Both the number of CP cases and its proportion in the total number of inpatients in the hospital increased rapidly. Alcohol (40.17%) and cholelithiasis (41.04%) were the most common risk factors of CP. CP of different etiologies had all increased, especially alcoholic CP, growing by an mean annual rate of 108.7%. 84.39%(292/346) of the patients presented with abdominal pain, 56.07% (194/346) had weight loss, 24.86% (86/346)had jaundice (all obstructive). Diabetes (25.14%, 87/346) was the most common complication. The median time of CP onset to occurrence of diabetes and fatty diarrhea were 1.00 year and 280.03 months, respectively. Diabetes occurred earlier in patients with autoimmune pancreatitis than those with idiopathic pancreatitis (P=0.020). Conclusions The incidence of CP is growing rapidly in China, with alcoholic CP increasing faster than biliary CP. The most common symptoms of CP are abdominal pain and weight loss, while the most common complication is diabetes. A patient database and regular follow-up visits could contribute to better understanding of epidemiological patterns of CP and improvement of its diagnosis and treatment.
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Objective We describe the first mouse model of pancreatic intraepithelial neoplasia (PanIN) lesions induced by alcohol in the presence and absence of chronic pancreatitis.
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Background/Aims: Population-based estimates for chronic pancreatitis (CP) are scarce. We determined incident CP hos-pitalization rates and the risk of pancreatitis-related readmis-sions in Allegheny County, Pennsylvania, USA. Meth...
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Background/Aims: Population-based estimates for chronic pancreatitis (CP) are scarce. We determined incident CP hos-pitalization rates and the risk of pancreatitis-related readmis-sions in Allegheny County, Pennsylvania, USA. Methods: We used Pennsylvania Health Care Cost Containment Council (PHC4) dataset to identify all unique White and Black Allegheny County residents with incident hospitalization for CP from years 1996-2005. We noted presence of alcoholism codes (from one year before index hospitalization until last contact) and pancreatitis-related readmissions until the third quarter of 2007. Age-, sex-, and race-adjusted (to US 2000 population) rates/100,000 were calculated. Results: 988 unique County residents with incident hospitalization for CP were identified.
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Background: /Objectives: A recent Genome-wide Association Study (GWAS) in alcoholic chronic pancreatitis (ACP) identified a novel association with the CTRB1-CTRB2 (chymotrypsinogen Bl, B2) locus, linked to a 16.6 kb inversion that...
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Background: /Objectives: A recent Genome-wide Association Study (GWAS) in alcoholic chronic pancreatitis (ACP) identified a novel association with the CTRB1-CTRB2 (chymotrypsinogen Bl, B2) locus, linked to a 16.6 kb inversion that was confirmed in non-alcoholic chronic pancreatitis (NACP). Moreover, recent findings on the function of CTRB1 and CTRB2 suggest a protective role in pancreatitis development. The aim of the present study was to investigate the CTRB1-CTRB2 locus for rare genetic variants associated with chronic pancreatitis (CP).
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Alcoholic chronic pancreatitis (CP) is not usually diagnosed until the end stage of the disease, and hence enormous medical and social resources are consumed in the treatment of established alcoholic CP. With the aim of early diag...
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Alcoholic chronic pancreatitis (CP) is not usually diagnosed until the end stage of the disease, and hence enormous medical and social resources are consumed in the treatment of established alcoholic CP. With the aim of early diagnosis and prevention of alcoholic CP, we here propose “alcoholic pancreatopathy” as a new category of pancreatic disorder induced by alcohol intake. In addition to a history of excessive alcohol intake (>80 g/day), the presence of at least one of the following conditions establishes the diagnosis of alcoholic pancreatopathy:
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Chronic pancreatitis is a complex inflammatory condition characterised by irreversible damage to the pancreas. This article explores the pathophysiology of this condition and its effects on pancreatic function. It outlines the cau...
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Chronic pancreatitis is a complex inflammatory condition characterised by irreversible damage to the pancreas. This article explores the pathophysiology of this condition and its effects on pancreatic function. It outlines the causes and presenting features of chronic pancreatitis, as well as its effect on patients* quality of life and the changes to their lifestyle that are likely to be required. Chronic pancreatitis cannot be cured; therefore, treatment aims to control pain, manage problems associated with malabsorption, and assess and manage long-term complications that may develop, such as insulin dependence.
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Background The main cause of chronic pancreatitis (CP) is excessive alcohol consumption. On the other hand, only 5–10% of heavy drinkers develop chronic pancreatitis. We have only limited information regarding the pathogenic mech...
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Background The main cause of chronic pancreatitis (CP) is excessive alcohol consumption. On the other hand, only 5–10% of heavy drinkers develop chronic pancreatitis. We have only limited information regarding the pathogenic mechanism by which alcohol leads to the disease. Mutations of the PRSS1 and SPINK 1 have been mostly implicated in hereditary and idiopathic CP, but their presence in other types of this disease have also been reported.
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Pancreas divisum is the most common congenital variant of the pancreas; however, its clinical significance remains controversial. The purpose of our study was to determine the role of pancreas divisum in the development of chronic pancreatitis.
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Цель исследования. Выявление особенностей цитокинового статуса при хроническом панкреатите (ХП) в зависимости от этиологиче...
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Цель исследования. Выявление особенностей цитокинового статуса при хроническом панкреатите (ХП) в зависимости от этиологического фактора, стадии заболевания, наличия осложнений, проводимой терапии.Материалы и методы. У 72 больных диагностирован хронический алкогольный панкреатит (ХАЛ), у 38 больных - хронический билиарный панкреатит (ХБП). Контрольную группу составили 20 клинически здоровых лиц.Результаты. На ранних стадиях и пике обострения ХАП преобладало повышение концентрации штерлейкина-1/3 (ИЛ-Щ (951,1 +- 104,2 пг/мл), ИЛ-6 (172,8 +- 24,3 пг/мл), ИЛ-Х (432,6 +- 68,5 пг/мл; интерферона-у (ИФН-у) (823,3 +- 97,5 пг/мл), а-фактора некроза опухоли (а-ФНО) (158,7 +- 19,6 пг/мл). По мере стихания острых явлений и развития ренератор-но-восстановительных процессов содержание ИЛ-4 при ХП повышалось до 614,9 +- 64,6пг/мл. Выявлены достоверные различия по содержанию ЦК между больными ХАП без осложнений и с осложнениями. Содержание трансформирующего фактора роста-/3, (ТФР-р), стимулирующего формирование фиброза, у больных ХАП составило 627,8 +- 92,2 пг/мл, у больных ХАП с осложненным течением - 796,8 +- 102,5, в контроле - 40,2 +- 4,6 пг/мл (р < 0,05). На ранних стадиях обострения ХБП повышение концентрации ИЛ-/3 составило 527,2 +- 62,7 пг/мл, ИЛ-6 - 80,9 +- 11,4 пг/мл, ИЛ-8 - 290,4 +- 46,8 пг/мл, ИФН-у - 853,3 +- 91,6 пг/мл; а-ФНО - 79,7 +- 8,3 пг/мл, ТФР-р, - 534,1 +- 78,4 пг/мл. По мере стихания острых явлений и усиления регенераторно-восстановительных процессов повышалось содержание ИЛ-4 (226,7+- 32,4пг/мл).Заключение. ХП сопровождается увеличением содержания ЦК с различными функциональными свойствами, выраженными в различной степени в зависимости от этиологического фактора, вариантов течения, стадии заболевания, наличия осложнений.
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